김빛내리

교수

김빛내리 Kim, V. Narry

김빛내리
연구분야
분자생물학 생화학 세포생물학
Our lab currently researches RNA-mediated gene regulation. In particular, to investigate post-transcriptional gene regulation mediated by microRNAs (miRNAs), we employ biochemistry, molecular biology, as well as genetic, biophysical, and computational approaches.
miRNAs are small non-coding RNAs involved in virtually all functional aspects of eukaryotic cells, including embryonic development, cell differentiation and proliferation, cell death, energy metabolism, and antiviral defense. Because tight control of miRNA levels is critical for normal functioning in cells, the dysregulation of miRNAs is often associated with human diseases such as cancer.
The main focus of the lab has been on the mechanism of miRNA biogenesis. By proposing a model for the biogenesis of miRNAs and by identifying several key factors such as Drosha, we have made major contributions to the current understanding of how miRNAs are created and processed in animal cells. More recently, we have been investigating the function and regulation of miRNAs in cancer and stem cells. These studies may potentially provide new opportunities for cancer treatment and stem cell engineering.
학력/경력
학력
  • - 1994.10 - 1998.2 박사 : Biochemistry, Oxford University
  • - 1992.3 - 1994.2 석사: 서울대학교 미생물학과
  • - 1988.3 - 1992.2 학사: 서울대학교 미생물학과
경력
  • - 2014 - present Member, The Korean Academy of Science Technology
  • - 2014 – present Foreign Associate Member, National Academy of Sciences (NAS)
  • - 2014 – present Editorial Board, Molecular Cell
  • - 2013 – present Foreign Associate Member, European Molecular Biology Organization (EMBO)
  • - 2013 – present Professor, Seoul National University
  • - 2013 – 2014 Council Member, Presidential Advisory Council on Science and Technology
  • - 2012 – present Director, Center for RNA Research, Institute for Basic Science
  • - 2010 - present Editorial Board, Cell
  • - 2010 - present SNU Distinguished Fellow, Seoul National University
  • - 2008 - 2010 Associate Professor, Seoul National University
  • - 2006 - 2008 Council Member, Presidential Advisory Council on Science and Technology
  • - 2004 - 2008 Assistant Professor, Seoul National University
  • - 2001 - 2004 Research Assistant Professor, Seoul National University
  • - 1999 - 2001 Postdoctoral fellow, Howard Hughes Medical Institute, University of Pennsylvania
주요논문
  1. J. Lim, M. Ha, H. Chang, S. C. Kwon, D. K. Simanshu, D. J. Patel, and V. N. Kim (2014) "Uridylation by TUT4 and TUT7 marks mRNA for degradation" Cell, 159(6):1365-1376.
  2. M. Lee, Y. Choi, K. Kim, H. Jin, J. Lim, T. A. Nguyen, J. Yang, M. Jeong, A. J. Giraldez, H. Yang, D. J. Patel, and V. N. Kim (2014) "Adenylation of maternally inherited microRNAs by Wispy" Molecular Cell, 56(5):696-707.
  3. M. Lee, B. Kim and V. N. Kim (2014) "Emerging roles of RNA modifications: m6A and U-tail" Cell, 158:980-987.
  4. Y. Kim, J. H. Lee, J.-E. Park, J. Cho, H. Yi and V. N. Kim (2014) "PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator" Genes & Development, 28: 1310-1322.
  5. H. Chang, J. Lim, M. Ha, and V. N. Kim (2014) "TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications" Molecular Cell, 53(6):1044-1052.