안광석

교수

안광석 Ahn, Kwangseog

안광석
연구분야
면역학 바이러스학 세포생물학

1.   Nucleic-acid mediated immunity & Inflammation
· Innate immune sensing pathways of foreign RNA/DNA

· Innate immune sensing of endogenous retroviruses and inflammation

· Coupling of innate sensing with adaptive immunity 

· Role of SAMHD1 in RNA homeostasis


2.   Host & Virus Interaction
· Modulation of host microRNAs by viruses

· Mechanisms of microRNA turnover
· Role for viral long noncoding RNA genome

· Immune evasion by viruses

· Molecular mechanisms for SAMHD1 in HIV-1 restriction

 


학력/경력
학력
  • - 1994 Ph.D. : University of Illinois at Urbana-Champaign
  • - 1987 M.S. : Seoul National University
  • - 1985 B.S. : Seoul National University
경력
  • - 2006 - 2015 Director, National Creative Research Initiatives Center for Antigen Presentation
  • - 2004 - Present Professor, Seoul National University, Department of Biological Sciences
  • - 2002 - 2003 Visiting Professor, Oregon Health & Science University
  • - 1997 - 2004 Associate professor, Korea University
  • - 1996 - 1997 Scientist, Johnson & Johnson
  • - 1994 - 1996 Post-Doc, The Scripps Research Institute (San Diego), Dept. of Immunology)
주요논문
  1. Kim, S., Seo, D., Kim, D., Hong, Y., Chan, H., Baek, D., Kim, VN., Lee., S., and Ahn, K. Temporal landscape of micrRNA-mediated host-virus crosstalk during productive human cytomegalovirus infection. Cell Host & Microbe 17:838-851 (2015). Highlighted as "Featured Article".
  2. Ryoo, J., Choi, J., Oh, C., Kim, S., Seo, M., Kim, S-Y., Seo, D., Kim, J., White, TE., Brandariz-Nunez, A., Diaz-Griferero, A., Yun, C-H., Hollenbaugh, JA., Kim, B., Baek., D., and Ahn, K. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nature Medicine 20:936-941 (2014). Highlighted in NEWS AND VIEWS of the issue (p.808-809).
  3. Lee, S., Song, J., Kim, S., Kim, J., Hong, Y., Kim Y., Kim, D., Baek D., and Ahn, K. Selective Degradation of host MicroRNAs by an Intergenic HCMV Non-Coding RNA Accelerates Virus Production. Cell Host & Microbe 13:678-690 (2013). Selected as Faculty of 1000 RECOMMENDED paper.
  4. Kim, S., Lee, S., Shin, J., Kim, Y., Evnouchidou, I., Kim, D., Kim, Y-K., Kim, Y-E., Ahn, J-H., Riddell SR., Stratikos, E., Kim, V-N., and Ahn, K. Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1. Nature Immunology 12:984-991 (2011). Selected as Faculty of 1000 EXCEPTIONAL paper.
  5. Lee, S., Cho, K., Cho, S., Kim, I., Oh, C., and Ahn, K. Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation. EMBO J. 29:363-375 (2010)
  6. Park, B., Lee, S., Kim, E., Cho, K., Riddell, S. R., Cho, S., and Ahn, K. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell 127: 369-382. (2006). Selected as "Featured Article of the issue' and Faculty of 1000 EXCEPTIONAL paper.