명예교수
정진하 Chung, Chin Ha
연구분야
1. Role of protein modification by ubiquitin
● Control of caspase-independent apoptosis by reversible ubiquitination of AIF
● Control of cell migration by reversible ubiquitination of ?-Pix
2. Role of protein modification by ubiquitin-like proteins
● Control of p53-Mdm2 pathway by SUMO modification of hnRNP K
● Control of JNK signaling pathway by ISG15 modification of filamins
3. Structure and function of ATP-dependent HslVU protease in bacteria
● Control of caspase-independent apoptosis by reversible ubiquitination of AIF
● Control of cell migration by reversible ubiquitination of ?-Pix
2. Role of protein modification by ubiquitin-like proteins
● Control of p53-Mdm2 pathway by SUMO modification of hnRNP K
● Control of JNK signaling pathway by ISG15 modification of filamins
3. Structure and function of ATP-dependent HslVU protease in bacteria
학력/경력
학력
- - 1977-1979 University of Alabama Ph.D., Biochemistry
- - 1975-1977 University of Alabama M.S., Biochemistry
- - 1969-1973 Seoul National University B.S., Biology
경력
- - 2003-2005 Head, School of Biological Sciences, Seoul National University
- - 1999-present Member, Korean Academy of Science & Technology
- - 1999-2002 Director, Institute for Molecular Biology and Genetics
- - 1994-present Professor, Seoul National University
- - 1989-1992 Chairman, Dept. of Molecular Biology, Seoul National University
- - 1987-1993 Associate Professor, Seoul National University
- - 1983-1987 Assistant Professor, Seoul National University
- - 1979-1983 Research Associate, Harvard Medical School
주요논문
- Jeon YJ, Jo MG, Yoo HM, Hong SH, Park JM, Ka SH, Oh KH, Seol JH, Jung YK, Chung CH., 2012: Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest.
- Lee JM, Lee JS, Kim H, Kim K, Park H, Kim JY, Lee SH, Kim IS, Kim J, Lee M, Chung CH, Seo SB, Yoon JB, Ko E, Noh DY, Kim KI, Kim KK, Baek SH., 2012: EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex.. Mol Cell
- Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH, (2011) Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme. Cell Death & Differentiation.
- Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE, (2011) Structure of Ubiquitin-fold modifier 1 specific protease, UfSP2. The Journal of Biological Chemistry.
- Jeon YJ, Yoo HM, Chung CH. (2010) ISG15 and immune diseases, 2010: ISG15 and immune diseases. Biochim Biophys Acta, 1802(5), 485-496
- Jeon YJ, Choi JS, Lee JY, Yu KR, Ka SH, Kang SH, Oh KH, Baek SH, Kim KI, Zhang DE, Bang OS Chung CH (2009) ISG15 modification of filamin B negatively regulates type-I interferon-induced JNK signaling pathway. EMBO Rep 10: 374-380.
- Jeon YJ, Choi JS, Lee JY, Yu KR, Ka SH, Cho Y, Choi EJ, Baek SH, Seol JH, Park D, Bang OS, Chung CH, (2008) Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. Mol Biol Cell, 19(12), 5116-30