Laboratory of Molecular Cell Biology

Laboratory of Molecular Cell Biology

Seoul National University
Laboratory of Molecular Cell Biology

Laboratory of Molecular Cell Biology

Seoul National University
Laboratory of Molecular Cell Biology

Laboratory of Molecular Cell Biology

Seoul National University

Publications+ more

(2012) Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition, J. Cell. Physiol. 228: 890–902, 2013.
(2010) Novel p104 protein regulates cell proliferation through PI3K inhibition and p27Kip1 expression, BMB Reports. 43(3),199.
(2009) Involvement of AMP-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase in 8-Cl-cAMP-Induced Growth Inhibition, J. Cell. Physiol.. 218(), 104.
(2006) Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator–activated receptor α, Diabetes.. 55(), 2,562.
(2006) Rap1 and p38 MAPK Mediate 8-Chloro-cAMP-Induced Growth Inhibition in Mouse Fibroblast DT Cells, J. Cell. Physiol.. 209(), 1,039.
(2006) Identification of Jmjd1a as a STAT3 Downstream Gene in mES Cells., Cell Struct. Funct.. 31(), 53.
(2006) Jak2 and Tyk2 are necessary for lineage-specific differentiation, but not for the maintenance of self-renewal of mouse embryonic stem cells, BBRC. 351(), 682.
(2005) 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells., Cancer Res.. 65(), 4,896.
(2005) The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3., Mol. Biol. Cell.. 16(), 4,672.
(2004) 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation., J. Cell. Physiol.. 201(), 277.

Welcome to the
"Laboratory of Molecular Cell Biology"

1) Search for the genes regulated by STAT3 transcription factor Embryonic stem cells (ES cells) have a potential to differentiate into any tissues of the body. ES cell requires a cytokine, LIF (leukemia inhibitory factor) to maintain its traits and to proliferate. Without LIF it starts to differentiate into various tissues. Inhibition of differentiation by LIF is a critical event in the regulation of mammalian differentiation. This signal transduction pathway consists of LIF receptor and gp130 receptor. And STAT (signal transducer and activator of transcription) proteins have interesting roles during this process. STATs have two different roles such as signal transducers which are activated by membrane receptors or Jak kinase, and transcription factors which translocate into nucleus and regulate the transcription of specific genes. Based on these facts, our lab are searching for the genes regulated by STAT3 during early developmental stage using ChIP (chromatin immunoprecipitation) method.