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정구흥

명예교수

정구흥 Jung, Guhung

정구흥
연구분야
바이러스학 분자생물학 세포생물학 유전학
1. Host factors that participate in HBV replication
   - Analysis of interaction among HBV polymerase, heat shock protein and ε-RNA

2. Change of gene expression which is involved in regulation of NF-kB pathway at liver cell after virus infection

3. Mechanism of hepatocellular carcinogenesis
학력/경력
학력
  • - 1984.8-1989.5 박사 : Molecular Biology, University of Arizona
  • - 1982.8-1984.8 석사: University of Texas, Molecular Biology
  • - 1976.3-1978.2 석사: 서울대학교 생물교육과
  • - 1972.3-1976.2 학사: 서울대학교 생물교육과
경력
  • - 2000- 교수, 서울대학교 자연과학대학 생명과학부
  • - 1999-2000 교수, 서울대학교 생물교육과
  • - 1993-1999 부교수, 서울대학교 생물교육과
  • - 1989-1993 조교수, 서울대학교 생물교육과
  • - 1988-1989 post-doc Havard Medical School
주요논문
  1. Eunkyong Ko, Hyun-Wook Seo, Eun Sun Jung, Soomi Ju, Baek-hui Kim, Hyeki Cho, Yoon Jun Kim, Young Min Park, Jong-Seo Kim, and GUHUNG JUNG 2018: PI3Kδ is a new therapeutic target in hepatocellular carcinoma. Hepatology (2018)
  2. Hyun-Wook Seo, Joon Pyung Seo, and Guhung Jung 2018: Heat shock protein 70 and heat shock protein 90 synergistically increase hepatitis B viral capsid assembly. BBRC (2018)
  3. Eunkyong Ko, Jong-Seo Kim, Soomi Ju, Hyun-Wook Seo, Yeonji Chang, Jung-Ah Kang, Sung- Gyoo Park, and GUHUNG JUNG 2018: Oxidatively modified PDIA3 promotes DKC1‐mediated malignancy and survival of hepatocellular carcinoma cells. Hepatology (2018)
  4. Eunkyong Ko, Hyun-Wook Seo, GUHUNG JUNG, 2017: Telomere length and ROS levels are positively associated with a high risk of mortality and recurrence in hepatocellular carcinoma. Hepatology (2017)
  5. Jung-Ah Kang, Sang-Heon Park, Sang Phil Jeong, Min-Hee Han, Cho-Rong Lee, Kwang Min Lee, Namhee Kim, Mi-Ryoung Song, Murim Choi, Michael Ye, Guhung Jung, Won-Woo Lee, Soo Hyun Eom, Chul-Seung Park, and Sung-Gyoo Park, 2016: Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. PNAS (2016)
  6. Eunkyong Ko, Hyun-Wook Seo, Eun Sun Jung, Baek-hui Kim, GUHUNG JUNG, 2015: The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer. Oncotarget (2015)
  7. Eunkyong Ko, Eun Sun Jung, and GUHUNG JUNG, 2015: Telomerase Reverse Transcriptase Promoter Methylation Is Related to a Risk of Recurrence in Hepatocellular Carcinoma. Hepatology (2015)
  8. Yoon Sik Kim, Hyun Wook Seo, and GUHUNG JUNG, 2015: Reactive oxygen species promote heat shock protein 90-mediated HBV capsid assembly. Biochemical and Biophysical Research Communications (2015)
  9. Hyeon Seop Kim and GUHUNG JUNG, "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor" FEBS Letters (2014)
  10. Hyeon Seop Kim, and GUHUNG JUNG, "Notch1 increases Snail expression under high reactive oxygen species conditions in hepatocellular carcinoma cells" Free Radical Research (2014)
  11. Eunkyong Ko and GUHUNG JUNG, "Positive association of long telomeres with the invasive capacity of hepatocellular carcinoma cells" Biochemical and Biophysical Research Communications (2014)
  12. Heewon Jeong, Min-Hyung Cho, and GUHUNG JUNG, "Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly" FEBS letters (2014)
  13. Cho, M. Song, J. Kim, H. Park, S. & GUHUNG JUNG, "Structure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors" J. Enz. Inhib. Med. Chem. (2013)
  14. Cho, M.H., Jeong, H., Kim, Y.S., Kim, J., & GUHUNG JUNG, "2-Amino-N-(2,6-dichloropyridin-3-yl)acetamide derivatives as a novel class of HBV capsid assembly inhibitor" Journal of Viral Hepatitis (2013)
  15. Hyeon Seop Kim, Heewon Jeong, Seung-Oe Lim, GUHUNG JUNG. "Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1" BBRC (2013)
  16. Min-Hyung Cho, Jin-Su Song, Hie-Joon Kim, Sung-Gyoo Park, GUHUNG JUNG "Structure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors" J. of Enz. Inhib. and Med. Chem. (2012)
  17. Seung-Oe Lim, Hyeon Seop Kim, Xiaoyuan Quan, Sun-Min Ahn, Hongtae Kim, David Hsieh, Je Kyung Seong, GUHUNG JUNG "Notch1 binds and induces degradation of Snail in hepatocellular carcinoma" BMC Biology (2011)
  18. Xiaoyuan Quan, Seung-Oe Lim, GUHUNG JUNG "Reactive oxygen species downregulate catalase expression via methylation of a CpG Island in the Oct-1 promoter" FEBS Letters (2011)
  19. Seung-Oe Lim, Young Min Park, Hyeon Seop Kim, Xiaoyuan Quan, Jeong Eun Yoo, Young Nyun Park, Gi Hong Choi, GUHUNG JUNG "Notch1 Differentially Regulates Oncogenesis by Wildtype p53 Overexpression and p53 Mutation in Grade III Hepatocellular Carcinoma" Hepatology (2011)
  20. Hee Youn Shim, Xiaoyuan Quan, Young-Su Yi, GUHUNG JUNG "Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers" Virology (2011)
  21. Antony Hsieh,Hyeon-Seop Kim,Seung-Oe Lim,Dae-Yeul Yu, GUHUNG JUNG “Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/b-catenin signaling” Cancer Letters (2010)
  22. Ji Young Min,Seung-Oe Lim, GUHUNG JUNG “Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter” FEBS Letters (2010)
  23. Seung-Oe Lim, Hongtae Kim, GUHUNG JUNG “p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma” FEBS Letters (2010)
  24. Hye Rim Kim, Sae Hee Lee, GUHUNG JUNG “The hepatitis B viral X protein activates NF-κB signaling pathway through the up-regulation of TBK1” FEBS Letters (2009)
  25. Chul-Yong Park, Soo-Ho Choi, Sang-Min Kang, Ju-Il Kang, Byung-Yoon Ahn, Hoguen Kim, GUHUNG JUNG, Kang-Yell Choi, Soon B. Hwang; “Nonstructural 5A protein activates b-catenin signaling cascades: Implication of hepatitis C virus-induced liver pathogenesis” Journal of Hepatology (2009)
  26. Sung Gyoo Park, Ji Young Min, Chan Chung, Antony Hsieh, GUHUNG JUNG “Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx” Cancer Letters (2009)
  27. Hang Kang,Jaehoon Yu, GUHUNG JUNG “Phosphorylation of hepatitis B virus core C-terminally truncated protein(Cp 149) by PKC increases capsid assembly and stability” Biochem J (2008)
  28. Seung Oe Lim, Jin-mo Gu, Min Sook Kim, Hyun-soo Kim, Young Nyun Park, Cheol Keun Park, Jae Won Cho, Young Min Park, GUHUNG JUNG “Epigenetic Changes induced by reactive oxygen species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter” Gastroenterology (2008)
  29. Jin-Mo Gu, Seung Oe Lim, Young Min Park GUHUNG JUNG “A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion” FEBS J (2008)
  30. Jin-Mo Gu, Seung Oe Lim, Sae Jin Oh, So-Mi Yoon Jekyung Seong, GUHUNG JUNG “HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species” Virus Reseach (2008)
  31. Lee HH, Kim HS, Kang JY, Lee BI, Ha JY, Yoon HJ, Lim SO, GUHUNG JUNG and Suh SW "Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface." Proteins. (2007)
  32. Chung C, Park SG, Park YM, Joh JW and GUHUNG JUNG "Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation." cancer sci. (2007)
  33. Sung Gyoo Park, Chan Chung, Hang Kang, Ji-Yeon Kim and GUHUNG JUNG “Up- regulatino of Cyclin D1 by HBx is mediated by NF-kB2/Bcl3 complex through kB site of Cyclin D1 promoter” Journal of Biological Chemistr y(2006)
  34. Hyun Mi Ryu, Sung Gyoo Park, Sung Su Yea, Won Hee Jang, Young-Il Yang, GUHUNG JUNG “Gene Expression Analysis of Primary Normal Human Hepatocytes infected by Human Hepatitis B Virus” World Journal of Gastroenterology (2006)
  35. Hee Yong Kang, Seungkeun Lee, Sung Gyoo Park, Jaehoon Yu, Youngsoo Kim, and GUHUNG JUNG “Phosphorylation of hepatitis B virus core protein at Ser87 facilitates core assembly” Biochemical Journal (2006)
  36. Soo-Ho Choi, Kyu-Jin Park, Byung-Yoon Ahn, GUHUNG JUNG, Michael M. C. Lai, and Soon B. Hwang "Hepatitis C virus nonstructural 5B protein regulates TNF-α signaling through effects on cellular IκB kinase" Molecular and Cellular Biology (2006)
  37. Sung Gyoo Park, Taehyung Lee, Hee Yong Kang, Kunsoo Park, Kwang-Hyun Cho, and GUHUNG JUNG"The Influence of the Signal Dynamics of Activated Form of IKK on NF-κB and Anti-apoptotic Gene Expressions: A Systems Biology Approach" FEBS Letters (2006)
  38. S.J. Park, W.G. Yoon, J.S. Song, H.S. Jung, C.J. Kim, S.Y. Oh, B.H. Yoon, GUHUNG JUNG, H.J. Kim and T. Nirasawa "Proteome analysis of human amnion and amniotic fluid by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry" Proteomics (2006)
  39. Baeckkyoung SUNG, Vyacheslav OGAY, Jung Sun YOO, Hyung Suk YU, Byung-Cheon LEE, Chan CHUNG, GUHUNG JUNG and Kwang-Sup SOH "UV-A-Induced Activation of Bonghan Granules in Motion " Journal of International Society of Life Information Science (2005)
  40. Sung Gyoo Park, Hyun Mi Ryu, Seung Oe Lim, Yong-il Kim, Soon Bong Hwang, GUHUNG JUNG " Interferon-γ Inhibits Hepatitis B Virus-Induced NF-κB Activation through Nuclear Localization of NF-κB-inducing Kinase " Gastroenterology (2005)
  41. Seung Oe Lim, Sung Gyoo Park, Jun-hi Yoo, Young Min Park, Hie-Joon Kim, Kee-Taek Jang, Jae Won Cho, Byung Chul Yoo, Cheol Keun Park, GUHUNG JUNG “Expression of Heat Shock Proteins in Hepatitis B Virus-Related Hepatocellular Carcinomas and Dysplastic Nodules” World Journal of Gastroenterology (2005)
  42. Yongwook Choi, Sung Gyoo Park, Jun-hi Yoo and GUHUNG JUNG "Calcium ions affect the hepatitis B virus core assembly" Virology (2005)
  43. Sang Hun Lee, Sung Gyoo Park, Seung Oe Lim and GUHUNG JUNG "The hepatitis B virus X protein up-regulates lymphotoxin a expression in hepatocytes" BBA (2005)
  44. Dong Ho Woo, In-Seob Han and GUHUNG JUNG "Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway" Life Science (2004)
  45. Soo Min Lee ,Sung Gyoo Park, Esther Park, Jae Yeon Lee and GUHUNG JUNG "The 113th and 117th charged amino acids in the 5th alpha-helix of the HBV core protein are necessary for pgRNA encapsidation" Virus genes (2003)
  46. Won Kim and Seung Oe Lim, Jong-Seo Kim , Young Hee Ryu, Ji-Yeon Byeon, Hie-Joon Kim, Yong-Il Kim, Jin Seok Heo, Young Min Park and GUHUNG JUNG "Comparison of Proteome between Hepatitis B Virus- and Hepatitis C Virus- associated Hepatocellular Carcinoma" Clinical Cancer Research (2003)
  47. Sung Gyoo Park, Soo Min Lee, and GUHUNG JUNG "Antisense Oligodeoxynucleotides Targeted against Molecular Chaperonin Hsp60 Block HBV Replication" Journal of Biological Chemistry (2003)
  48. Sung Gyoo Park, Younhee Kim, Esther Park, Hyun Mi Ryu, and GUHUNG JUNG "Fidelity of Hepatitis B Virus Polymerase" European Journal of Biochemistry (2003)
  49. Young-Su Yi, Sung Gyoo Park, Sung Moo Byeon, Young-Guen Kwon, and GUHUNG JUNG "Hepatitis B Virus X Protein Induces TNF-α Expression via Down-Regulation of Selenoprotein P in Human Hepatoma Cell Line, HepG2" BBA (2003)
  50. Jaesun chun, Taegun Kwon, Dae Joong Kim, Ingun park, GUHUNG JUNG, Eun Jeoung Lee, Soon Kwang Hong, Soo-Ik Chanf, Hack Young Kim and Sang Sun Kang "Inhibition of Mitogen-Activated Kinase Kinase Kinase 3 Activity through Phosphorylation by the Serum- and Glucocorticoid-Induced Kinase 1" Jounal of Biochemistry (2003)
  51. SungGyoo Park, Seung Oe Lim, and GUHUNG JUNG"Binding Site Analysis of Human HBV Pol for Molecular Chaperonin, Hsp60" Virology (2002)
  52. SungGyoo Park and GUHUNG JUNG. “Hsp90 makes the human HBV Pol competent for in vitro priming rather than maintaining the human HBV Pol/pregenomic RNA complex” Arch Biochem Biophys (2002)
  53. Jun-hi Yoo and GUHUNG JUNG "Hepatitis B Virus Carries a Foreign Gene into Liver Cells in Vitro" Virus Genes (2002)
  54. Seung Oe Lim, Sung-Jun Park, Won Kim, SungGyoo Park, Hie-Joon Kim, Yong-Il Kim, Tae-Sung Sohn, Jae-Hyung Noh, and GUHUNG JUNG."Proteome analysis of hepatocellular carcinoma" Biochem Biophys Res Commun. (2002)
  55. SungGyoo Park, GUHUNG JUNG. "Human Hepatitis B Virus Polymerase Interacts with the Molecular Chaperonin Hsp60" Journal of Virology, (2001)
  56. Ginam Cho, Se Won Suh, GUHUNG JUNG . "HBV Polymerase Interacts Independently with N-Terminal and C-Terminal Fragments of Hsp90 " Biochem Biophys Res Commun., (2000)
  57. Ginam Cho, Sung-Gyoo Park, GUHUNG JUNG."Localization of HSP90 Binding Sites in the Human Hepatitis B Virus Polymerase" Biochem Biophys Res Commun. (2000)
  58. Younhee Kim, GUHUNG JUNG. "Active human hepatitis B viral polymerase expressed in rabbit reticulocyte lysate system" Virus and Genes (1999)
  59. Younhee Kim, Young bin Hong and GUHUNG JUNG. "Hepatitis B Virus : DNA Polymerase Activity of Delection Mutants" Biochemistry and Molecular Biology Internatioal (1999)
  60. Young Il Lee, Young Bin Hong, Younhee Kim, Hyune Mo Rho, and GUHUNG JUNG, "RNase H Activity of Human Hepatitis B Virus Polymerase Expressed in E. coli" Biochem. Biophy. Res. Comm. (1997)
  61. Ginam Cho, Sangsun Kang, Seong Jin Seo, Younhee Kim, and GUHUNG JUNG, "The Transcriptional Repression of the Human Gu/Zu Superoxide Dismutase(sod1) Gene by the Anticancer Drug ,Nitomycin C(mmc)", Biochemistry and Molecular Biology International (1997)
  62. Seong Jin Seo , Sang Sun Kang, Ginam Cho, Hyune Mo Rho, GUHUNG JUNG. "C/EBPα and C/EBPβ play similar roles in the transcription of the human Cu/Zu Gene", GENE (1997)
  63. Young Ho Kim, Hae Yong Yoo, Mun Seog Chang, GUHUNG JUNG, Hyune Mo Rho. "C/EBPα is a major activator for the transcription of rat Cu/Zn superoxide dismutase gene in liver cell". FEBS (1997)
  64. Na-ri Lee, Moon-ok Hwang, GUHUNG JUNG, Young-soo Kim and Kyung-hee Min, "Physical Structure and Expression of alk BA Encoding Alkane Hydroxylase and Rubred-oxin Reductase from Pseudomonas maltophilia" Biochem. Biophy. Res. Comm. (1996)
  65. Ji Hoon Jeong, Dong Seok Kwak, Hyune Mo Rho, and GUHUNG JUNG, "The Catalytic Properties of Human Hepatitis B Virus Polymerase", Biochem. Biophy. Res. Comm (1996)
  66. Seong Jin Seo, Hong Tae Kim, Ginam Cho, Hyune Mo Rho, GUHUNG JUNG. "Sp1 and C/EBP-regulated factor regulate the transcription of human Cu/Zu SOD gene" Gene (1996)
  67. Ginam Cho, GUHUNG JUNG. "Structure-function analysis of the DNA binding domain of Saccharomyces cerevisiae ABF1" Nucleic Acids Research (1995)
  68. Junhi Yoo, GUHUNG JUNG. "DNA uptake by imbibition and expression of a foreign gene in rice", Physiologia Plantarum (1995)
  69. Hae-young Yoo, GUHUNG JUNG and Hyun-mo Rho. "Transcriptional Control of saccaromyces cervisiae ADH1 Gene by Autonomously Replicating sequence binding Factor 1" Current Microbiology (1995)
  70. Kim,H.T, Kim,Y.H, Nam,J.H, Lee,H.J, Rho,H,M, GUHUNG JUNG “Study of 5’-flanking region of human Cu/Zn superoxide dismutase” Biochem.Biophys.Res.commum (1994)
  71. Wiguo Zhu, Mark C.Leavitl, GUHUNG JUNG,J Ito. “Mutagenesis of a highly conserved lys340 of the PRD1 DNA polymerase” Biochim. Biophys. Acta (1994)
  72. Han- Joo Lee. Yong-tae Kwon, Hyun-mo Rho and Guhung Jung "Expression of Hepatitis B virus polymerase Gene in E-coli" Biotechnology Letters (1993)
  73. Yong-ho Kim, GUHUNG JUNG, Ji-young Kim and Hyun-mo Rho "Isolation and analysis of the Cu/Zu superoxide dismutase" GENE (1993)
  74. Jung, G amp; J. Ito "Site-specific mutagenesis of PRD1 DNA polymerase : Mutation in highly conserved region of the family B DNA polymerase " Biochem. Biophys. Res. comm. (1990)
  75. GUHUNG JUNG Leavitt, M.C. Hsieh, J. & Ito, J. "Bacteriophage, PRD1 DNA polymerase : Evolution of DNA polymerase" Proc. Nalt. Acad. Sci. U.S.A (1987)
  76. Hsieh, J. GUHUNG JUNG Leavitt, M.C. & Ito, J. "Primary structure of the DNA terminal protein of bacteriophage PRD1" Nucleic Acids Res. (1987)
  77. GUHUNG JUNG Leavitt, M.C. & Ito, J. "Yeast Killer plasmid pGKL1 encoded a DNA polymerase belong to a family B DNA polymerase" Nucleic Acids Res (1987)
08826 서울시 관악구 관악로1 서울대학교 자연과학대학 생명과학부 분자유전학 연구실
drjung@snu.ac.kr · 02-880-4424
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