Seoul National University Biological Sciences Website

Publications

Laboratory of Apoptosis & Molecular Disease

Archives of Pharmacal Research

Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Ji-Eun Bae, Joon Bum Kim, Hyun Jun Park, Ji Yeon Choi, Ha Jung Lee, Jeong Ho Chang, Heeyoun Bunch, Hong Bae Jeon, Yong-Keun Jung, Dong-Hyung Cho (2021). Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Archives of Pharmacal Research, 44(6), 621-631.

Autophagy

Seo-Hyun Kim, Young-Sin Cho, Youbin Kim, Jisu Park, Seung-Min Yoo, Jimin Gwak, Youngwon Kim, Youngdae Gwon, Tae-In Kam, Yong-Keun Jung (2023). Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. Autophagy, (), 1-20.

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E Adamopoulos, Khosrow Adeli, Timon E Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N Agrewala, Alexander Agrotis, Patricia V Aguilar, S Tariq Ahmad, Zubair M Ahmed, Ulises Ahumada-Castro, Yong-Keun Jung, etc. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1-382.

Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K Kim, Yong-Keun Jung, Jae-Young Koh, Seong-Kyu Choe, Kyu-Sun Lee, Dong-Hyung Cho (2020). Loss of HSPA9 Induces Peroxisomal Degradation by Increasing Pexophagy. Autophagy, (), 1-15.

Ji Hyun Shin, So Jung Park, Doo Sin Jo, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Yoon Kyung Jo, Jung Jin Hwang, Jin-A Lee, Dong-Gyu Jo, Jin Cheon Kim, Yong Keun Jung, Jae-Young Koh, Dong-Hyung Cho (2019). Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation. Autophagy, 15(9), 1495-1505.

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ…..Jung YK et al (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222.

Sungwoo Park, Seon-Guk Choi, Seung-Min Yoo, Jin H Son, Yong-Keun Jung (2014). Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy. Autophagy, 10(11), .

Jihoon Nah, Jong-Ok Pyo, Sunmin Jung, Seung-Min Yoo, Tae-In Kam, JaeWoong Chang, Jonghee Han, Seong Soo A An, Takashi Onodera, Yong-Keun Jung (2013). BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42. Autophagy, 9(12), 2009-2021.

Young Mi Song, Sun-Ok Song, Yong-Keun Jung, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee (2012). Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction. Autophagy, 8(7), 1085-1097.

Klionsky DJ, Abdalla FC, ..., Jung CH, Jung YK, Kaarniranta K, ..., Zschocke J, Zuckerbraun B (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544.

Jong-Ok Pyo, Jihoon Nah, Hyo-Jin Kim, Ho-June Lee, Jungun Heo, Heuiran Lee, Yong-Keun Jung (2008). Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Autophagy, 4(3), 315-321.

Biochem Biophys Res Commun

Jo DG, Chang JW, Hong HS, Mook-Jung I, Jung YK (2003). Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis. Biochem Biophys Res Commun, 305(1), 62-66.

Biochemical and Biophysical Research Communications

Yong-Keun Jung (2019). Highlighting Apoptosis in Neuronal Injury. Biochemical and Biophysical Research Communications, 520(4), 681.

YoungDoo Kim, Hyejin Park, Jihoon Nah, Seowon Moon, WonJae Lee, Se-Hoon Hong, Tae-In Kam, Yong-Keun Jung (2015). Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. Biochemical and Biophysical Research Communications, 462(2), 112-8.

Gab Seok Kim, Young Ae Park, Yong Seok Choi, Yun-Hee Choi, Hyun Woo Choi, Yong-Keun Jung, Sunjoo Jeong (2006). Suppression of receptor-mediated apoptosis by death effecter domain recruiting domain binding peptide aptamer. Biochemical and Biophysical Research Communications, 343(4), 1165-1170.

Biological Psychiatry

Youbin Kim, Hyejin Park, Youngwon Kim, Seo-Hyun Kim, Jae Hoon Lee, Hanseul Yang, Seo Jin Kim, Cathena Meiling Li, Haneul Lee, Do-Hyeong Na, Seowon Moon, Yumi Shin, Tae-In Kam, Han-Woong Lee, SangYun Kim, Ji-Joon Song, Yong-Keun Jung (2022). Pathogenic Role of RAGE in Tau Transmission and Memory Deficits. Biological Psychiatry, (), .

BMB Reports

Seung-Min Yoo, Jisu Park, Seo-Hyun Kim, Yong-Keun Jung (2020). Emerging Perspectives on Mitochondrial Dysfunction and Inflammation in Alzheimer's Disease. BMB Reports, 53(1), 35-46.

Br J Cancer

Kim IK, Jung YK, Noh DY, Song YS, Choi CH, Oh BH, Masuda ES, Jung YK (2003). Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2. Br J Cancer, 88(6), 910-917.

Brain Pathology

Jong-Sung Park, Silvia Manzanero, Jae-Woong Chang, Yuri Choi, Sang-Ha Baik, Yi-Lin Cheng, Yu-I Li, A-Ryeong Gwon, Ha-Na Woo, Jiyeon Jang, In-Young Choi, Joo-Yong Lee, Yong-Keun Jung, Sung-Chun Tang, Christopher G Sobey, Thiruma V Arumugam, Dong-Gyu Jo (2013). Calsenilin contributes to neuronal cell death in ischemic stroke. Brain Pathology, 23(4), 402-412.

British Journal of Cancer

Hyeryeong Kim, Jee Young Sung, Eun-Kyung Park, Seongho Kho, Kyung Hee Koo, Seog-Yun Park, Sung-Ho Goh, Yoon Kyung Jeon, Sekyung Oh, Byung-Kiu Park, Yong-Keun Jung*, Yong-Nyun Kim* (2017). Regulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor. British Journal of Cancer, 116(3), 370-381.

Cancer Lett

Lee MW, Park SC, Kim JH, Kim IK, Han KS, Kim KY, Lee WB, Jung YK, Kim SS (2002). The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells. Cancer Lett, 182(1), 75-82.

Cancer Research

Hyeonjeong Lee, Yumin Oh, Young-Jun Jeon, Song-Yi Lee, Hyunjoo Kim, Ho-June Lee, Yong-Keun Jung (2019). DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death.. Cancer Research, 79(11), 2839-2852.

Carcinogenesis

Kim BJ, Kim MS, Kim KB, Kim KW, Hong YM, Kim IK, Lee HW, Jung YK (2002). Sensitizing effects of cadmium on TNF-alpha- and TRAIL-mediated apoptosis of NIH3T3 cells with distinct expression patterns of p53. Carcinogenesis, 23(9), 1411-1417.

Cardiovascular Research

Jihoon Nah, Akihiro Shirakabe, Risa Mukai, Peiyong Zhai, Eun-Ah Sung, Andreas Ivessa, Wataru Mizushima, Yasuki Nakada, Toshiro Saito, Chengchen Hu, Yong-Keun Jung, Junichi Sadoshima (2022). Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Cardiovascular Research, (), .

Cell Death & Disease

Hyunjoo Kim*, Muhah Jeong*, Do-Hyeong Na, Shin-Hyeon Ryu, Eun Il Jeong, Kwangmin Jung, Jaemin Kang, Ho-June Lee, Taebo Sim, Dae-Yeul Yu, Hee Chul Yu, Baik-Hwan Cho, Yong-Keun Jung (2022). AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis. Cell Death & Disease, 13(5), 469.

Ji-Eun Bae, Gil Myung Kang, Se Hee Min, Doo Sin Jo, Yong-Keun Jung, Keetae Kim, Min-Seon Kim, Dong-Hyung Cho (2019). Primary Cilia Mediate Mitochondrial Stress Responses to Promote Dopamine Neuron Survival in a Parkinson's Disease Model. Cell Death & Disease, 10(12), 952.

Song-Yi Lee, Hyunjoo Kim, Cathena Meiling Li, Jaemin Kang, Ayaz Najafov, Muhah Jung, Soosung Kang, Shaomeng Wang, Junying Yuan, Yong-Keun Jung (2019). Casein kinase-1γ1 and 3 Stimulate Tumor Necrosis Factor-Induced Necroptosis Through RIPK3. Cell Death & Disease, 10(12), 923.

Bitna Lim, Kwangmin Jung, Youngdae Gwon, Jae Gyun Oh, Jae-Il Roh, Se-Hoon Hong, Changwon Kho, Woo-Jin Park, Han-Woong Lee, Jang-Whan Bae, Yong-Keun Jung (2019). Cardioprotective Role of APIP in Myocardial Infarction Through ADORA2B. Cell Death & Disease, 10(7), 511.

Jihoon Nah, Seung-Min Yoo, Sunmin Jung, Eun Il Jeong, Moonju Park, Bong-Kiun Kaang, Yong-Keun Jung (2017). Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress. Cell Death & Disease, 8(5), e2822.

Eun Il Jeong, Hae Won Chung, Won Jea Lee, Seo-Hyun Kim, Hyunjoo Kim, Seon-Guk Choi, Yong-Keun Jung (2016). E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion. Cell Death & Disease, 7(12), e2573.

Cell Death Differ

Oh Y, Jeon YJ, Hong GS, Kim I, Woo HN, Jung YK (2012). Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells. Cell Death Differ, 19(7), 1196-1207.

Choi H, Chang JW, Jung YK (2011). Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase. Cell Death Differ, 18(3), 405-414.

Cell Reports

Jonghee Han, Junho Hyun, Jaesang Park, Sunmin Jung, Yoonseo Oh, Youbin Kim, Shin-Hyeon Ryu, Seo-Hyun Kim, Eun Il Jeong, Dong-Gyu Jo, Sung-Hye Park, Yong-Keun Jung (2021). Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease. Cell Reports, 37(10), .

Sang Mi Shim, Won Jae Lee, Youngdoo Kim, Jong Wook Chang, Sungmin Song, Yong-Keun Jung (2012). Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes. Cell Reports, 2(3), 603-615.

Cell Signaling

Sungwoo Park*, Seon-Guk Choi*, Seung-Min Yoo, Jihoon Nah, Eunil Jeong, Hyunjoo Kim, Yong-Keun Jung (2015). Pyruvate Stimulates Mitophagy via PINK1 Stabilization. Cell Signaling, 27(9), 1824-30.

Cells

Ji-Eun Bae, Joon Bum Kim, Doo Sin Jo, Na Yeon Park, Yong Hwan Kim, Ha Jung Lee, Seong Hyun Kim, So Hyun Kim, Mikyung Son, Pansoo Kim, Hong-Yeoul Ryu, Won Ha Lee, Zae Young Ryoo, Hyun-Shik Lee, Yong-Keun Jung, Dong-Hyung Cho (2022). Carnitine Protects against MPP+-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells. Cells, 11(17), 2722.

Cellular and Molecular Life Sciences

Tae-In Kam, Youngdae Gwon, Yong-Keun Jung (2014). Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease. Cellular and Molecular Life Sciences, 71(24), 4803-13.

Jonghee Han, Sunmin Jung, Jiyeon Jang, Tae-In Kam, Hyunwoo Choi, Byung-Ju Kim, Jihoon Nah, Dong-Gyu Jo, Toshiyuki Nakagawa, Masaki Nishimura, Yong-Keun Jung (2014). OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin. Cellular and Molecular Life Sciences, 71(13), 2561-2576.

Sang Mi Shim, Won Jae Lee, Hae Won Chung, Yong-Keun Jung (2011). Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity. Cellular and Molecular Life Sciences, 68(12), 2115-2127.

Cytokine

Kim KB, Choi YH, Kim IK, Chung CW, Kim BJ, Park YM, Jung YK (2002). Potentiation of Fas- and TRAIL-mediated apoptosis by IFN-gamma in A549 lung epithelial cells: enhancement of caspase-8 expression through IFN-response element. Cytokine, 20(6), 283-288.

Diabetes & Metabolism Journal

Jong-Ok Pyo, Seung-Min Yoo, Yong-Keun Jung (2013). The interplay between ageing and autophagy. Diabetes & Metabolism Journal, 37(5), 333-339.

eLife

Tae-In Kam*, Hyejin Park*, Youngdae Gwon*, Sungmin Song, Seo-Hyun Kim, Seo Won Moon, Dong-Gyu Jo, Yong-Keun Jung (2016). FcγRIIb-SHIP2 axis links amyloid-β to tau pathology by disrupting phosphoinositide metabolism in Alzheimer’s disease model. eLife, 5(), e18691.

European Journal of Medicinal Chemistry

Soo-Jeong Choi, Joong-Heui Cho, Isak Im, So-Deok Lee, Ji-Yeon Jang, Yu-Min Oh, Yong-Keun Jung, Eun-Seok Jeon, Yong-Chul Kim (2010). Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors. European Journal of Medicinal Chemistry, 45(6), 2578-2590.

Exp Mol Med

Cho CW, Poo H, Cho YS, Cho MC, Lee KA, Lee SJ, Park SN, Kim IK, Jung YK, Choe YK, Yeom YI, Choe IS, Yoon DY (2002). HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing.. Exp Mol Med, 34(2), 159-166.

Experimental & Molecular Medicine

Jong Ok Pyo, Jihoon Nah, Yong Keun Jung (2012). Molecules and their functions in autophagy. Experimental & Molecular Medicine, 44(2), 73-80.

FASEB Journal

Seung-Min Yoo, Shun-Ichi Yamashita, Hyunjoo Kim, DoHyeong Na, Haneul Lee, Seo Jin Kim, Dong-Hyung Cho, Tomotake Kanki, Yong-Keun Jung (2020). FKBP8 LIRL-dependent Mitochondrial Fragmentation Facilitates Mitophagy Under Stress Conditions. FASEB Journal, 34(2), 2944-2957.

Youngdae Gwon, Seo-Hyun Kim, Hyun Tae Kim, Tae-In Kam, Jisu Park, Bitna Lim, Hyunju Cha, Ho-Jin Chang, Yong Rae Hong, Yong-Keun Jung (2019). Amelioration of Amyloid β-FcγRIIb Neurotoxicity and Tau Pathologies by Targeting LYN. FASEB Journal, 33(3), 4300-4313.

FEBS Lett

Hong YM, Jo DG, Lee JY, Chang JW, Nam JH, Noh JY, Koh JY, Jung YK (2003). Down-regulation of ARC contributes to vulnerability of hippocampal neurons to ischemia/hypoxia. FEBS Lett, 543(1-3), 170-173.

FEBS Letters

Hye-Hyun Ahn, Yumin Oh, Huikyong Lee, WonJae Lee, Jae-Woong Chang, Ha-Kyung Pyo, Do hyung Nah, Yong-Keun Jung (2015). Identification of glucose-6-phosphate transporter as a key regulator functioning at the autophagy initiation step. FEBS Letters, 589(16), 2100-9.

Yoshihiro Suzuki, Kazunori Ohta, Masanori Itoh, Yukari Sakoh-Sumitomo, Teruhiko Mitsuda, Masashi Ueda, Yoshika Hayakawa-Yano, Shimo Li, Yoko Hida, Takashi Inuzuka, Yong-Keun Jung, Toshiyuki Nakagawa (2009). An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Letters, 583(9), 1403-1408.

Ha-Na Woo, Gil-Sun Hong, Joon-Il Jun, Dong-Hyung Cho, Hyun-Woo Choi, Ho-June Lee, Chul-Woong Chung, In-Ki Kim, Dong-Gyu Jo, Jong-Ok Pyo, John Bertin, Yong-Keun Jung (2004). Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. FEBS Letters, 578(3), 239-244.

Free Radical Biologya and Medicine

Cheol-Hee Choi, Yong-Keun Jung, Seon-Hee Oh (2010). Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines. Free Radical Biologya and Medicine, 49(2), 245-257.

Gene

Choi I, Woo JM, Hong S, Jung YK, Kim DH, Cho C (2003). Identification and characterization of ADAM32 with testis-predominant gene expression. Gene, 304(), 151-162.

Genomics

Choi I, Oh J, Cho BN, Ahnn J, Jung YK, Han Kim D, Cho C (2004). Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Genomics, 83(4), 636-646.

Hum Mol Genet

Hyejin Park, Tae-In Kam, Youngdoo Kim, Hyunwoo Choi, Youngdae Gwon, Changsoo Kim, Jae-Young Koh, Yong-Keun Jung (2012). Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. Hum Mol Genet, 21(12), 2725-2737.

Human Molecular Genetics

Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Kim (2020). Ca2+-permeable TRPV1 Pain Receptor Knockout Rescues Memory Deficits and Reduces Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Human Molecular Genetics, 29(2), 228-237.

Huikyong Lee, Jee-Yeon Noh, Yumin Oh, Youngdoo Kim, Jae-Woong Chang, Chul-Woong Chung, Soon-Tae Lee, Manho Kim, Hoon Ryu, Yong-Keun Jung (2012). IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Human Molecular Genetics, 21(1), 101-114.

Jae-Woong Chang, Hyunwoo Choi, Hyun-Ji Kim, Dong-Gyu Jo, Young-Jun Jeon, Jee-Yeon Noh, Woo Jin Park, Yong-Keun Jung (2007). Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin. Human Molecular Genetics, 16(3), 317-326.

J Biol Chem

Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (2004). Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. J Biol Chem, 279(38), 39942-39950.

Ryu SW, Lee SJ, Park MY, Jun JI, Jung YK, Kim E (2003). Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J Biol Chem, 278(26), 24003-24010.

J Cell Biochem. 2002;85(2):334-45

Kim KW, Kim BJ, Chung CW, Jo DG, Kim IK, Song YH, Kwon YK, Woo HN, Jung YK (2002). Caspase cleavage product lacking amino-terminus of IkappaBalpha sensitizes resistant cells to TNF-alpha and TRAIL-induced apoptosis. J Cell Biochem. 2002;85(2):334-45, 85(2), 334-345.

J Neurochem

Jo DG, Lee JY, Hong YM, Song S, Mook-Jung I, Koh JY, Jung YK (2004). Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. J Neurochem, 88(3), 604-611.

Journal of Neuroscience

Youngdae Gwon, Tae-In Kam, Seo-Hyun Kim, Sungmin Song, Hyejin Park, Bitna Lim, Haneul Lee, Weontae Lee, Dong-Gyu Jo, Yong-Keun Jung (2018). TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease. Journal of Neuroscience, 38(42), 9001-9018.

Journal of Biochemistry and Molecular Biology

Gil-Sun Hong, Yong-Keun Jung (2002). Caspase recruitment domain (CARD) as a bi-functional switch of caspase regulation and NF-kappaB signals. Journal of Biochemistry and Molecular Biology, 35(1), 19-23.

Journal of Biological Chemistry

Sunggeon Ko, Gil Bu Kang, Sung Min Song, Jung-Gyu Lee, Dong Yeon Shin, Ji-Hye Yun, Yi Sheng, Chaejoon Cheong, Young Ho Jeon, Yong-Keun Jung, Cheryl H Arrowsmith, George V Avvakumov, Sirano Dhe-Paganon, Yung Joon Yoo, Soo Hyun Eom, Weontae Lee (2010). Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity. Journal of Biological Chemistry, 285(46), 36070-36080.

Jee-Yeon Noh, Huikyong Lee, Sungmin Song, Nam Soon Kim, Wooseok Im, Manho Kim, Hyemyung Seo, Chul-Woong Chung, Jae-Woong Chang, Robert J Ferrante, Young-Jun Yoo, Hoon Ryu, Yong-Keun Jung (2009). SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. Journal of Biological Chemistry, 284(17), 11318-11325.

Jong-Ok Pyo, Jihoon Nah, Hyo-Jin Kim, Jae-Woong Chang, Young-Wha Song, Dong-Kwon Yang, Dong-Gyu Jo, Hyung-Ryong Kim, Han-Jung Chae, Soo-Wan Chae, Seung-Yong Hwang, Seung-Jun Kim, Hyo-Joon Kim, Chunghee Cho, Chang-Gyu Oh, Woo Jin Park, Yong-Keun Jung (2008). Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. Journal of Biological Chemistry, 283(45), 30707-30714.

Sungeun Hong, Inchul Choi, Jong-Min Woo, Jungsu Oh, Taewan Kim, Eunyoung Choi, Tae-Wan Kim, Yong-Keun Jung, Do Han Kim, Choong-Hyun Sun, Gwan-Su Yi, Edward M Eddy, Chunghee Cho (2005). Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Journal of Biological Chemistry, 280(9), 7685-7693.

Jong-Ok Pyo, Mi-Hee Jang, Yun-Kyung Kwon, Ho-June Lee, Joon-Il Jun, Ha-Na Woo, Dong-Hyung Cho, Boyoun Choi, Heuiran Lee, Joo-Hang Kim, Noboru Mizushima, Yoshinori Oshumi, Yong-Keun Jung (2005). Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. Journal of Biological Chemistry, 280(21), 20722-20729.

Journal of Cell Biology

Sungmin Song, Huikyong Lee, Tae-In Kam, Mei Ling Tai, Joo-Yong Lee, Jee-Yeon Noh, Sang Mi Shim, Soo Jung Seo, Young-Yun Kong, Toshiyuki Nakagawa, Chul-Woong Chung, Deog-Young Choi, Hammou Oubrahim, Yong-Keun Jung (2008). E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. Journal of Cell Biology, 182(4), 675-684.

Journal of Neurochemistry

Young Doo Kim*, Eun Il Jeong*, Jihoon Nah, Seung-Min Yoo, Won Jae Lee, Youbin Kim, Seowon Moon, Se-Hoon Hong, Yong-Keun Jung (2017). Pimozide reduces toxic forms of tau in TauC3 mice via AMPK-mediated autophagy. Journal of Neurochemistry, 142(5), 734-746.

Sunmin Jung, Jihoon Nah, Jonghee Han, Seon-Guk Choi, Hyunjoo Kim, Jaesang Park, Ha-Kyung Pyo, Yong-Keun Jung (2016). Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting Amyloid Precursor Protein axonal transport during hypoxia. Journal of Neurochemistry, 137(5), 770–781.

Tae-Yong Choi, Sunmin Jung, Jihoon Nah, Hui-Yeon Ko, Su-Hyun Jo, Gehoon Chung, Kyungpyo Park, Yong-Keun Jung, Se-Young Choi (2015). Low levels of methyl β-cyclodextrin disrupt GluA1-dependent synaptic potentiation but not synaptic depression. Journal of Neurochemistry, 132(3), 276-285.

Jae-Woong Chang, Hyunwoo Choi, Susan L Cotman, Yong-Keun Jung (2011). Lithium rescues the impaired autophagy process in CbCln3(Δex7/8/Δex7/8) cerebellar cells and reduces neuronal vulnerability to cell death via IMPase inhibition. Journal of Neurochemistry, 116(4), 659-668.

Sooyeon Jo, Kwang-Hee Lee, Sungmin Song, Yong-Keun Jung, Chul-Seung Park (2005). Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. Journal of Neurochemistry, 94(5), 1212-1224.

Life Sciences

Do-Sung Kim, Eun-Rhan Woo, Soo-Wan Chae, Ki-Chan Ha, Geum-Hwa Lee, Seong-Tshool Hong, Dae-Young Kwon, Myung-Sunny Kim, Yong-Keun Jung, Hyung-Min Kim, Hye-Kyung Kim, Hyung-Ryong Kim, Han-Jung Chae (2007). Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation. Life Sciences, 80(4), 314-323.

Mol Cell

Song S, Kim SY, Hong YM, Jo DG, Lee JY, Shim SM, Chung CW, Seo SJ, Yoo YJ, Koh JY, Lee MC, Yates AJ, Ichijo H, Jung YK (2003). Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity. Mol Cell, 12(3), 553-563.

Mol Cell Biol

Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH, Shim SM, Lee HJ, Cho C, Kim DH, Jung YK (2004). Calcium binding of ARC mediates regulation of caspase 8 and cell death. Mol Cell Biol, 24(22), 9763-9770.

Molecular and Cellular Biology

Seon-Guk Choi, Hyunjoo Kim, Eun Il Jeong, Ho-June Lee, Sungwoo Park, Song-Yi Lee, Hyeon-Jeong Lee, Seong Won Lee, Chin Ha Chung, Yong-Keun Jung (2017). SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis. Molecular and Cellular Biology, 37(2), e00254-16.

Molecular Brain

So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo, Dong-Hyung Cho (2021). Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells. Molecular Brain, 14(1), 6.

Molecular Neurobiology

Huikyong Lee, Hye-Hyun Ahn, WonJae Lee, Yumin Oh, Hyunwoo Choi, Sang Mi Shim, Jaekyoon Shin, Yong-Keun Jung (2016). ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress. Molecular Neurobiology, 53(10), 6620-6634.

Molecular Pharmacology

Cheol-Hee Choi, Yong-Keun Jung, Seon-Hee Oh (2010). Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. Molecular Pharmacology, 78(1), 114-125.

Molecular Psychiatry

Jisu Park*, Hyunwoo Choi*, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jung (2021). Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular Psychiatry, (), .

Molecules and Cells

Seung-Min Yoo, Yong-Keun Jung (2018). A molecular approach to mitophagy and mitochondrial dynamics. Molecules and Cells, 41(1), 18-26.

Jihoon Nah, Junying Yuan, Yong-Keun Jung (2015). Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach. Molecules and Cells, 38(5), 381-389.

Nature Cell Biology

Ho-June Lee, Jong-Ok Pyo, Yumin Oh, Hyo-Jin Kim, Se-hoon Hong, Young-Jun Jeon, Hyunjoo Kim, Dong-Hyung Cho, Ha-Na Woo, Sungmin Song, Jung-Hyun Nam, Hyo Joon Kim, Key-Sun Kim, Yong-Keun Jung (2007). AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10. Nature Cell Biology, 9(11), 1303-1310.

Nature Communnications

Hyunjoo Kim, Ho-June Lee, Yumin Oh, Seon-Guk Choi, Se-Hoon Hong, Hyo-Jin Kim, Song-Yi Lee, Ji-Woo Choi, Deog Su Hwang, Key-Sun Kim, Hyo-Joon Kim, Jianke Zhang, Hyun-Jo Youn, Dong-Young Noh, Yong-Keun Jung (2014). The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nature Communnications, 5(), 3351.

Jong-Ok Pyo, Seung-Min Yoo, Hye-Hyun Ahn, Jihoon Nah, Se-Hoon Hong, Tae-In Kam, Sunmin Jung, Yong-Keun Jung (2013). Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nature Communnications, 4(), 2300.

Neurobiol Dis

Chung CW, Hong YM, Song S, Woo HN, Choi YH, Rohn T, Jung YK (2003). Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death. Neurobiol Dis, 14(3), 557-566.

Neurobiology of Disease

YoungDoo Kim*, Hyunwoo Choi*, WonJae Lee, Hyejin Park, Tae-In Kam, Se-Hoon Hong, Jihoon Nah, Sunmin Jung, Bora Shin, Huikyong Lee, Tae-Yong Choi, Hyosun Choo, Kyung-Keun Kim, Se-Young Choi, Rakez Kayed, Yong-Keun Jung (2016). Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiology of Disease, 87(), 19-28.

Neuroreport

Ha-Na Woo, Jae-Woong Chang, Yun-Hyung Choi, A-Ryeong Gwon, Yong-Keun Jung, Dong-Gyu Jo (2008). Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3. Neuroreport, 19(12), 1193-1197.

Neurosci Lett

Hong YM, Jo DG, Lee MC, Kim SY, Jung YK (2003). Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients. Neurosci Lett, 340(1), 33-36.

Neuroscience Letters

Dong-Gyu Jo, Jiyeon Jang, Byung-Ju Kim, Johan Lundkvist, Yong-Keun Jung (2005). Overexpression of calsenilin enhances gamma-secretase activity. Neuroscience Letters, 378(1), 59-64.

Oncogene

Jeon YJ, Kim IK, Hong SH, Nan H, Kim HJ, Lee HJ, Masuda ES, Meyuhas O, Oh BH, Jung YK (2008). Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling. Oncogene, 27(31), 4344-4352.

Cho DH, Lee HJ, Kim HJ, Hong SH, Pyo JO, Cho C, Jung YK (2007). Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2. Oncogene, 26(19), 2809-2814.

Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK (2005). Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway. Oncogene, 24(4), 688-696.

Kim JY, Kim YH, Chang I, Kim S, Pak YK, Oh BH, Yagita H, Jung YK, Oh YJ, Lee MS (2002). Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis. Oncogene, 21(20), 3139-3148.

Oncotargets

Se-Hoon Hong*, Won Jae Lee*, Young Doo Kim, Hyunjoo Kim, Young-Jun Jeon, Bitna Lim, Dong-Hyung Cho, Won Do Heo, Doo-Hyun Yang, Chan-Young Kim, Han-Kwang Yang, Jin Kuk Yang, Yong-Keun Jung (2016). APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. Oncotargets, 7(16), 21601-21617.

PLoS One

Hye-Eun Han, Saravanan Sellamuthu, Bae Hyun Shin, Yong Jae Lee, Sungmin Song, Ji-Seon Seo, In-Sun Baek, Jeomil Bae, Hannah Kim, Yung Joon Yoo, Yong-Keun Jung, Woo Keun Song, Pyung-Lim Han, Woo Jin Park (2010). The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β. PLoS One, 5(12), e15645.

PNAS

Choi JY, Qiao Q, Hong SH, Kim CM, Jeong JH, Kim YG, Jung YK, Wu H, Park HH (2017). CIDE domains form functionally important higher-order assemblies for DNA fragmentation. PNAS, 114(28), 7361-7366.

Wonchull Kang, Se Hoon Hong, Hye Min Lee, Na Yeon Kim, Yun Chan Lim, Le Thi My Le, Bitna Lim, Hyun Chul Kim, Tae Yeon Kim, Hiroki Ashida, Akiho Yokota, Sang Soo Hah, Keun Ho Chun, Yong-Keun Jung, Jin Kuk Yang (2014). Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. PNAS, 111(1), 54-61.

Hyo-Jin Kim, Ho-June Lee, Joon-Il Jun, Yumin Oh, Seon-Guk Choi, Hyunjoo Kim, Chul-Woong Chung, In-Ki Kim, Il-Sun Park, Han-Jung Chae, Hyung-Ryong Kim, Yong-Keun Jung (2009). Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53. PNAS, 106(36), 15326-15331.

Proc Natl Acad Sci U S A

Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim DH, Cho C, Liu JO, Snyder SH, Jung YK (2002). Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc Natl Acad Sci U S A, 99(15), 9870-9875.

Science Signaling

Jung S*, Hyun J*, Nah J, Han J, Kim SH, Park J, Oh Y, Gwon Y, Moon S, Jo DG, Jung YK (2020). SERP1 Is an Assembly Regulator of γ-Secretase in Metabolic Stress Conditions. Science Signaling, 13(623), eaax8949.

Scientific Reports

WonJae Lee, YoungDoo Kim, Jisu Park, SangMi Shim, Jieun Lee, Se-hoon Hong, Hye-Hyun Ahn, Huikyong Lee, Yong-Keun Jung (2015). iRhom1 regulates proteasome activity via PAC1/2 under ER stress. Scientific Reports, 10(), 1038.

The Journal of Clinical Investigation

Tae-In Kam, Sungmin Song, Youngdae Gwon, Hyejin Park, Ji-Jing Yan, Isak Im, Ji-Woo Choi, Tae-Yong Choi, Jeongyeon Kim, Dong-Keun Song, Toshiyuki Takai, Yong-Chul Kim, Key-Sun Kim, Se-Young Choi, Sukwoo Choi, William L Klein, Junying Yuan, Yong-Keun Jung (2013). FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation, 123(7), 2791-2802.

Young Joo Jeon, Mi Gyeong Jo, Hee Min Yoo, Se-Hoon Hong, Jung-Mi Park, Seung Hyeun Ka, Kyu Hee Oh, Jae Hong Seol, Yong Keun Jung, Chin Ha Chung (2012). Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. The Journal of Clinical Investigation, 122(7), 2622-2636.

Trends Mol Med

Song S, Jung YK (2004). Alzheimer's disease meets the ubiquitin-proteasome system. Trends Mol Med, 10(11), 565-570.