Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University
Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University
Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University

Publications+ more

(2017) A protocol for imaging of the Drosophila visceral muscle, Protocol Exchange
(2017) Misato underlies visceral myopathy in Drosophila, Scientific Reports
(2017) Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH), PLOS Genetics
(2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye, Developmental Cell
(2017) Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death, Journal of Biological Chemistry

Welcome to the
"Laboratory of Molecular Genomics"

Cell growth regulation Our laboratory studies various signal transduction pathways involved in the regulation of cell proliferation and differentiation. Specifically, we focus on ERK-MAPK pathway mediating growth factor-dependent cell growth regulation, TOR/S6K and LKB1/AMPK pathways mediating nutrient-dependent cell growth regulation, and JNK-MAPK pathway regulating cell death. To understand detailed functional mechanisms of cell growth regulation, we have generated various gain-of-function and loss-of-function mutants for the components of each signaling in Drosophila and characterized their roles in cell growth regulation. By examining their genetic interactions with each other, we are trying to expand our understanding for the global signaling network regulating cell growth. Moreover, through biochemical approaches using mammalian cell culture system, we study the detailed molecular mechanisms on how these molecules function and interact with each other in the process of cell growth regulation.