2021-03-19l Hit 3126
New Paradigms in Cancer Metabolism and Metastasis
Hyun Woo Park
Department of Biochemistry, Yonsei University, Seoul 03722, Korea
Our lab focuses on novel therapeutic strategies to target cancer metabolism and metastasis. We developed ‘Cancer metabolism-based synthetic lethality platform (CM-SLP)’, a metabolite sensitive drug screening platform that identifies and repurposes FDA-approved drugs for anticancer treatment. CM-SLP aims to establish a new paradigm termed ‘Oncometabolic precision medicine’ and initiate metabolite-based personalized medicine. We also discovered a novel biological phenomenon termed ‘Epithelial-Hematopoietic Conversion (EHT)’ that reprograms adherent cells into suspension cells via defined factors. We aim to establish this novel paradigm to reveal undescribed mechanisms and key players underlying cancer dissemination and metastasis, and further develop new anti-metastatic drugs.
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