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세미나 담당교수 : 2023-2학기 김진홍 (금요세미나, 콜로퀴움, jinhkim@snu.ac.kr), 강찬희 (신진과학자세미나, chanhee.kang@snu.ac.kr), 윤태영 (10-10 project, tyyoon@snu.ac.kr)
조 교 : 장사라 (02-880-4431, jsarah@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Epigenetic mechanisms underlying brain function

2022-04-21l 조회수 1056

일시: 2022-04-22 11:00 ~ 13:00
발표자: Kim, Tae-Kyung (POSTECH Department of Life Sciences)
담당교수: 생명과학부
장소: 대면 | Mokam Hall https://snu-ac-kr.zoom.us/j/97429456635
Epigenetic mechanisms underlying brain function

Tae-Kyung Kim

Dept of Life Sciences, POSTECH, Pohang, Republic of Korea

Long non-coding RNAs (lncRNAs) have been increasingly appreciated as
an integral component in gene regulatory networks. Genome-wide features
of their origin and expression patterns ascribed a prominent role for
lncRNAs to the regulation of protein-coding genes, and also suggest a
potential link to many human diseases. Recent studies have begun to
unravel the intricate regulatory mechanism of lncRNAs occurring at
multiple levels. We have previously discovered that a novel class of
lncRNAs, termed as enhancer RNA (eRNA), is dynamically expressed
from functionally active neuronal enhancers. Unlike other lncRNAs, the
induction of eRNA is rapid and transient, and tightly regulated by external
stimuli such as neuronal activity. Epigenomic analyses in many different
cell types unequivocally suggest that eRNA is a hallmark of functionally
active enhancers. This feature of eRNAs has enabled us to investigate the
molecular function of eRNAs in gene expression and brain function, and
dynamic coordination mechanism of enhancer clusters that ensures robust
induction of target genes in response to various stimuli. We are also
investigating the biogenesis mechanism of eRNAs. Our studies collectively
suggest that transcription at enhancers and eRNAs might represent a new
layer of complexity in the molecular architecture of many human diseases.