세미나/행사

  • Home
  • 정보센터
  • 세미나/행사
  • 세미나/행사
세미나 담당교수 : 2023-2학기 김진홍 (금요세미나, 콜로퀴움, jinhkim@snu.ac.kr), 강찬희 (신진과학자세미나, chanhee.kang@snu.ac.kr), 윤태영 (10-10 project, tyyoon@snu.ac.kr)
조 교 : 장사라 (02-880-4431, jsarah@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Deciphering novel host-virus interactions using a CRISPR activation screening

2022-03-10l 조회수 1074

일시: 2022-03-11 11:00 ~ 13:00
발표자: Sanghyun Lee (Brown University)
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/87879082258
Viruses exploit cellular surface proteins in multiple phases of viral life cycle, including
cellular entry. We employ an unbiased screening method using the CRISPR activation
(CRISPRa) technique, named surfaceome CRISPRa library. The surfaceome library
covers ~6000 of all known/predicted surface proteins on the cellular plasma membrane.
The surfaceome screening with viral proteins identified several novel cellular genes
interacting with pathogenic viruses. This talk will cover two new findings. First, discovery
of human LRRC15 (leucine rich repeat containing 15) as a novel inhibitory receptor for
SARS-CoV-2. Second, a novel cellular receptor for secreted viral protein of a norovirus.
Furthermore, we will explore the contribution of secreted viral protein of noroviruses to
chronic viral infection in the intestine.