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세미나 담당교수 : 2023-2학기 김진홍 (금요세미나, 콜로퀴움, jinhkim@snu.ac.kr), 강찬희 (신진과학자세미나, chanhee.kang@snu.ac.kr), 윤태영 (10-10 project, tyyoon@snu.ac.kr)
조 교 : 장사라 (02-880-4431, jsarah@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Microbiota-induced vitamin A transport and its role in the intestinal immunity

2021-12-21l 조회수 1210

일시: 2021-12-20 11:00 ~ 13:00
발표자: Ye-Ji Bang (UT Southwestern Medical Center)
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/84487151126
Vitamin A and its derivative retinol are essential for the development of intestinal adaptive
immunity. Retinoic acid (RA)-producing myeloid cells are central to this process, but how
myeloid cells acquire retinol for enzymatic conversion to RA is unknown. Here, we show that
serum amyloid A (SAA) proteins, retinol binding proteins induced in intestinal epithelial cells by
the microbiota, deliver retinol to myeloid cells. We identify LDL receptor-related protein 1 (LRP1)
as an SAA receptor that facilitates endocytosis of SAA-retinol complexes and promotes retinol
acquisition by RA-producing intestinal myeloid cells. Consequently, SAA and LRP1 are
essential for vitamin A-dependent immunity, including T and B cell homing to the intestine and
immunoglobulin A production. Our findings identify a key mechanism underpinning vitamin A’s
effects on the immune system and provide molecular insight into how the microbiota promotes
intestinal immunity.