일시: 2023-01-04 11:00 ~ 13:00
발표자: Jonathan Gootenberg (MIT McGovern Institute)
담당교수: 생명과학부
장소: 대면 | 목암홀(Mokam Hall)
As we further understand the complexity and diversity of cellular states, it is becoming necessary
for a cellular engineering toolbox, consisting of molecular tools that allow control over cell states
and types. Drawing from a combination of natural discovery and rational engineering, I will
discuss my lab's recent work in this area. I will cover RNA, DNA, and cell targeting approaches,
including the novel CRISPR effector, Cas7-11, that can be used to target transcripts in
mammalian cells for degradation, with reduced toxicity; a new genome insertion system,
PASTE, that enables efficient, programmable insertion of large DNA segments into the genome
without limitations of previous genome editing approaches; and a new approach for control of
cell states, RADARS, that can sense and react to transcript levels in cells. These technologies
form the basis for new approaches to manipulate and understand cellular states, with implications
in basic biology, diagnostics, and therapeutics.