일시: 2022-08-29 10:30 ~ 12:30
발표자: Donghyun Park (Scripps Research)
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/95329758920
Targeting bacterial nanomachinery: Visualizing host-pathogen interactions in situ
The “Resolution Revolution” by single particle cryo-electron microscopy (cryo-EM) allowed
high-resolution structural analysis of macromolecules that have been challenging to tackle with
Xray crystallography and NMR. The next “revolution” in biology will be led by approaches that
directly reveal high-resolution details of critical processes in their native context. Cryo-electron
tomography (cryo-ET) is a uniquely suited imaging technique to determine in-situ structures, and
thereby also mechanisms, of macromolecular complexes. Our lab utilizes advanced cryo-ET
techniques to study how bacterial pathogens use complex multiprotein nanomachines to inject
bacterial substrate into target cells to achieve infection and survival.