[초청강연] Illuminating neural circuits: from molecules to MRI for precision brain health

Abstract:

Starting from the first observations of neurons, neuroscientists have strived to understand how the neurons are connected and communicate with each other. Owing to astonishing technological advancements, we are now able to measure multiple aspects of neuronal organization including their molecular pathways, electrical activity, and large-scale functional changes. However, we still lack a comprehensive understanding that can concretely describe how any particular behavior is controlled. Beyond the lack of understanding, this also means that when abnormal behavior arise in neurological disease such as tremors, neuropsychiatric disorders, or memory loss, it is impossible to figure out exactly how the function should be restored. In this talk, we demonstrate an approach putting the puzzle together by an intelligent, systematic combination of brain function signal measurements, manipulations, and modeling, starting from MRI scale going down to single unit recordings and molecular mechanisms with the goal of treating neurological disease.