[대학원장학] NIH 이경상 박사님의 Postdoctoral Positions 모집 공고 입니다

NIH 이경상 박사님의 Postdoctoral Positions 모집 공고 입니다.

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Polo Kinase in Mitotic Control, Tumorigenesis, and Anti-cancer Therapy

Dr. Kyung Lee (kyunglee@mail.nih.gov)
National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda,
MD 20892, U. S. A.

I am looking for a postdoctoral fellow who has an interest in studying the function of mammalian polo-like kinase 1 (Plk1) and its interacting proteins in normal and cancer cell proliferation. Plk1 plays a pivotal role in proper mitotic progression and its eregulation is tightly associated with oncogenesis. Potential projects include, but are not imited to, the differential roles of Plk1 and its associated proteins during cell cycle progression, tumorigenesis, and stem cell/cancer stem cell proliferation.

Applicants should be a Ph.D. or M.D. with less than 3 years of postdoctoral experience. Expertise in cell biology, biochemistry, and stem biology is preferred. Visit https://ccrod.cancer.gov/confluence/display/CCRKLEE/Home for additional information.

Selected Publications:

Kang, Y.-H., et al. 2006. Self-regulated Plk1 recruitment to kinetochores by the Plk1- PBIP1 interaction is critical for proper chromosome segregation. Mol. Cell 24:409-422.

Soung NK, et al. 2009. Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells. Dev. Cell 16: 539-550.

Park JE, et al. 2009. Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay. PNAS USA. 106:1725-1730.

Yun SM, et al. 2009. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat. Str. & Mol. Biol. 16:876-882.

Park, J. -E., et al. 2011. Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate. PNAS USA. 108:8200-5.

Johmura Y, et al. 2011. Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.  PNAS USA. 108:11446-11451.

Liu F, et al. 2011. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat. Chem. Biol. 7:595-601.

Lee, K H., et al. 2012. Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 31:3104-17.

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.