최성화

교수

최성화 Choe, Sunghwa

최성화
연구분야
발달 및 발생생물학 분자생물학 생물정보학 생화학 식물과학 유전체학 유전학

Brassinosteroids (BRs) collectively refer to the plant steroid hormones, which were first isolated from pollen of rape plants belonging to the Brassicaceae family. The chemical structure of brassinolide, the most active compounds among more than 50 BRs identified to date, was determined in 1979 after X-ray crystallography. However, the importance of these compounds as plant growth-promoting hormones was re-discovered in 1990s after extensive research on Arabidopsis mutants that are defective in either biosynthesis or signaling pathways of BRs.

 

The primary effects of BRs in plant biology include stimulation of cell division and differentiation. Especially, BR deficient mutants display characteristic phenotypes attributable to retarded elongation of the cells. Furthermore, BRs are central to control xylem tissue development. More recently, their roles in regulation of plant stress responses are being revealed.

 

We are primarily interested in genetic and biochemical elucidation of the whole biosynthetic pathways of BRs, and their regulation. In addition, we aim to reveal the evolutionary mechanisms of interaction of these pathways with other plant hormones such as auxin, salicylic acid, jasmonic acid, ethylene, gibberellins, cytokinins, and abscisic acid.

 

Our understanding on BR biology will lead to development of crop plants that possess the novel traits conferring an increase in yield of grain or biomass production.

학력/경력
학력
  • - 1994.8-1997.12 이학박사: 애리조나 대학교 (투산) 식물과학 및 생화학 Ph.D. University of Arizona (Plant Sciences and Biochemistry)
  • - 1989.3-1991.2 이학석사: 서울대학교 식물학과 Master of Science, Seoul National University
  • - 1984.3-1989.2 이학사: 서울대학교 식물학과 Bachelor of Science, Seoul National University
경력
  • - 2014 - 소장, SNU&G 컨텍아카데미
  • - 2013 - 교수, 서울대학교 생명과학부
  • - 2012 - 부원장, 차세대융합기술연구원
  • - 2008 ~ 2009 객원교수, Univ of Wisconsin Madison, 생명공학센터
  • - 2006 ~ 2012 부교수, 서울대학교 생명과학부
  • - 2001 ~ 2006 조교수, 서울대학교 생명과학부
  • - 2000 ~ 2001 Scientist, Ceres, Inc.
  • - 1998 ~ 2000 Research scientist, University of Arizona
  • - 1994 ~ 1997 국비유학장학생, 교육부
  • - 1991 ~ 1993 Systems engineer, IBM Korea
주요논문
  1. Yu Jeong Jeong, Slki Park, Su Jeoung Suh, Soon Il Kwon, Richard Cha, Yoong Eun Kim, Sunghwa Choe, 2016: Overexpression of the 3’ half of the PHYB partially suppresses dwarfism in the brassinosteroid-insensitive bri1-5 mutant. Journal of Plant Biology, 59(1), 83-91
  2. Je Wook Woo, Jungeun Kim, Soon Il Kwon, Claudia Corvalán, Seung Woo Cho, Hyeran Kim, Sang-Gyu Kim, Sang-Tae Kim, Sunghwa Choe, Jin-Soo Kim, 2015: DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins. Nature biotechnology, 33, 1162–1164, doi:10.1038/
  3. Yu Jeong Jeong, Claudia Corvalán, Soon Il Kwon, Sunghwa Choe, 2015: Analysis of anti-BZR1 antibody reveals the roles BES1 in maintaining the BZR1 levels in Arabidopsis. Journal of Plant Biology, 58(2), 87-95
  4. Yuhee Chung, Soon Il Kwon, Sunghwa Choe, 2014: Antagonistic Regulation of Arabidopsis Growth by Brassinosteroids and Abiotic Stresses. Mol. Cells, 37(11), 795-803
  5. Puna M. Maharjan, Brian P. Dilkes, Shozo Fujioka, Aleš Pěnčík, Karin Ljung, Meike Burow, Barbara A. Halkier, Sunghwa Choe, 2014: Arabidopsis gulliver1/superroot2-7 identifies a metabolic basis for auxin and brassinosteroid synergy. the Plant Journal, 80(5), 797–808