성노현

교수

성노현 Seong, Rho Hyun

성노현
연구분야
면역학 분자생물학
1. T-cell Differentiation in the thymus
● Genetic and epigenetic control of T cell differentiation
● Control of thymocyte selection by transcription factors and chromatin remodeling complex

2. Differentiation of regulatory T-cells and Th17 cells in the periphery
● Control of regulatory T-cell development by transcription factors and chromatin remodeling complex
● Signaling factors regulating the differentiation and function of colonic Treg and Th17 cells

3. Regulation of early hematopoietic cell differentiation in the bone marrow
● Control of early B cell differentiation by chromatin remodeling complex and hematopoietic stromal cell factors
● Control of peripheral B cell differentiation by signaling factors

4. Genetic and epigenetic analysis of disease development
● Intestinal Bowel Diseases, Liver diseases using liver organoid culture
학력/경력
학력
  • - 2003.4-현재 정교수
  • - 1997.2-2003.3 부교수
  • - 1993.3-1997.2 조교수
  • - 1983.10-1990.1 박사 : 스텐포드대학교
  • - 1981.3-1983.2 석사: 서울대학교 대학원 동물학과
  • - 1977.3-1981.2 학사: 서울대학교 동물학과
경력
  • - 1994.12-1996.11 학술간사, 한국동물학회
  • - 1995.12-현재 이사, 대한면역학회
  • - 1996.12-현재 이사, 한국동물학회
  • - 1996.12-2000.11 편집간사, 한국생물과학협회지
  • - 1997.4-2003.5 위원, 서울대학교 국제백신연구소 설립추진기획단
  • - 1999.1-2003.1 장장, 서울대학교 실험동물사육장
  • - 2001.1-2002.12 편집간사, Molecules and Cells ( 한국분자세포생물학회지)
  • - 2002.5-2007.3 국제연구자문위원, 국제백신연구소
  • - 2003.3-2006.2 설립추진위원/기획운영부장, 서울대학교 생명공학공동연구원
  • - 2004.1-현재 이사/상임이사/감사, 국제백신연구소 한국후원회
  • - 2005.6-2014.2 소장, 세포기능제어연구센터(SRC)
  • - 2005.1-2005.12 총무운영위원, 한국분자세포생물학회
  • - 2007.1-2008.12 사무총장, 제9회 세계세포생물학회 조직위원회
  • - 2010.1-2010.12 학술위원장, 한국분자세포생물학회
  • - 2011.3-2012.2 회장, 교육과학기술부 지원 우수연구센터(S/ERC) 소장 협의회
  • - 2012.2-2012.7 학부장, 서울대학교 생명과학부
  • - 2012.7-2014.7 처장/산학협력단장, 서울대학교 연구처
  • - 2013-2016 국제연구자문위원, 국제백신연구소
  • - 2015.1-2017.12 편집위원장, Molecules and Cells (한국분자세포생물학회지)
  • - 2015.4-현재 소장, 서울대학교 유전공학연구소
주요논문
  1. Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6" for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
  2. Bachmann, C, H. Nguyen , J. Rosenbusch , L. Pham, T. Rabe, M. Patwa, G. Sokpor, R.H. Seong, R. Ashery-Padan, A. Mansouri, A. Stoykova, J.F. Staiger, T. Tuoc. 2016. mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet. 12(9):e1006274 DOI: 10.1371/ journal.pgen.1006274.
  3. Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
  4. Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
  5. Panamarova, M., A. Cox, K. Wicher, R. Butler, N.A. Bulgakova, S. Jeon, B. Rosen, R.H. Seong, W. Scarnes, G. Crabtree, and M. Zernicka-Goetz. 2016. BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development. 143:1271-1283.
  6. Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
  7. Narayanan, R., M. Pirouz, C. Kerimoglu, L. Pham, R. Wagener, K. Kiszka, J. Rosenbusch, R.H. Seong, M. Kessel, A. Fischer, A. Stoykova, J.F. Staiger, and T. Tuoc. 2015. Loss of entire multi-subunit BAF (mSWI/SNF) complexes impairs global epigenetic programs in forebrain development. Cell Reports. 13(9):1842-1854.
  8. Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.
  9. Kim, S, K. Park, J. Choi, E. Jang, D.-J. Paik, R.H. Seong∗ and J. Youn∗. 2015. Foxp3+ regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow. Eur. J. Immunol. 45: 167-179. (*co-corresponding authors).
  10. Park T.-Y., S.-D. Park, J.-Y. Cho, J.-S. Moon, N.-Y. Kim, K. Park, R.H. Seong, S.-W. Lee, T. Moriod, A.L.M. Bothwelle, and S.-K. Lee. 2014. RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells. Proc. Natl. Acad. Sci. 111(52), 18673-18678.
  11. Kim, J., S.K. Lee, Y. Jeon, Y. Kim, C. Lee, S.H. Jeon, J. Shim, I.-H. Kim, S. Hong, N. Kim, H. Lee and R.H. Seong. 2014. TopBP1 deficiency impairs V(D)J recombination during lymphocyte development. EMBO J. 33(3). 217-228.
  12. Choi, J., M. Ko, S. Jeon, Y. Jeon, K. Park, C. Lee, H. Lee, and R.H. Seong. 2012. The SWI/SNF-like BAF Complex Is Essential for Early B Cell Development. J. Immunol. 188: 3791- 3803.