Associate Professor
Kim, Jin-Hong
Research
Cell Biology
Molecular Biology
The research interest of our lab is in revealing the molecular mechanisms underlying musculoskeletal diseases (osteoarthritis, tendinopathy, and sarcomas) and developing therapeutic strategies against these diseases.
Education/Career
Education
- - 2005-2010 Ph.D., Bioengineering, Caltech
- - 2001-2005 B.BmE , Biomedical Engineering, University of Minnesota
Career
- - 2019.9 - present Seoul National University, Associate Professor
- - 2018 ~ present IBS, Center for RNA research, the RNA therapeutics team leader
- - 2021 - 2022 Dana-Farber Cancer Institute / Harvard Medical School, Visiting scholar
- - 2014.9 - 2019.8 Seoul National University, Assistant Professor
- - 2010 - 2014 Gwangju Institute of Science and Technology, Research Professor
- - 2010 - 2010.10 Caltech, Division of Chemistry and Chemical Engineering, Post-doc
Publications
- Cho Y*, Kim H*, Yook G*, Yong S, Kim S, Lee N, Kim YJ, Kim J, Kim TW, Chang MJ, Lee KM, Chang CB, Kang SB, Kim JH# (2024) IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development. Arthritis & Rheumatology
- Suh J*, Kim H*, Min J, Yeon HJ, Hemberg M, Scimeca L, Wu MR, Kang HG, Kim YJ#, and Kim JH# (2024) Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis. Cell Reports Medicine [Cover] [Backstory]
- Roh K*, Noh J*, Kim Y, Jang Y, Kim J, Choi H, Lee Y, Ji M, Kang D, Kim MS, Paik MJ, Chung J, Kim JH#, and C Kang# (2023) Lysosomal control of senescence and inflammation through cholesterol partitioning. Nature Metabolism
- Kang D*, Lee J*, Jung J, Carlson BA, Chang MJ, Chang CB, Kang SB, Lee BC, Gladyshev VN, Hatfield DL, Lee BJ#, and Kim JH# (2022) Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Nature Communications
- Cho Y*, Kim HS*, Kang D, Kim H, Lee N, Yun J, Kim YJ , Lee KM , Kim J, Kim HR, Hwang YI, Jo CH, and Kim JH# (2021) CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition. Science Advances
- Kim H*, Cho Y*, Kim HS, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG and Kim JH# (2020). A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nature Communications
- Kim S*, Han S*, Kim Y, Kim HS, Gu YR, Kang D, Cho Y, Kim H, Lee J, Seo Y, Chang MJ, Chang CB, Kang SB, and Kim JH# (2019). Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation. Nature Communications
- Kang D*, Shin J*, Cho Y, Kim HS, Gu YR, Kim H, You KT, Chang MJ, Chang CB, Kang SB, Kim JS, Kim VN, and Kim JH# (2019). Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development. Science Translational Medicine
- Won Y, Shin Y, CH Chun, Cho Y, Ha C, Kim JH#, and Chun JS# (2016). Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis. Annals of the Rheumatic Diseases
- Lee M, Won Y, Shin Y, Kim JH#, and Chun JS# (2015). Reciprocal activation of hypoxia-inducible factor (HIF)-2 and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis. Osteoarthritis Cartilage
- Kim JH, Jeon J, Shin M, Won Y, Lee M, Kwak JS, Lee G, Rhee J, Ryu JH, Chun CH, Chun JS (2014). Regulation of the catabolic cascade in osteoarthritis by the zinc•ZIP8•MTF1 axis. Cell