Professor
Seong, Rho Hyun
Research
Immunology
Molecular Biology
1. T-cell Differentiation in thymus
● Control of cell differentiation and proliferation of thymocytes by pre-TCR and TCR signaling
● Control of positive and negative selection by chromatin remodeling complex
2. Biogenesis of regulatory T-cells
● Control of regulatory T-cell development by chromatin remodeling complex
3. Role of transcription factor,Twist2 in T cell development
● Control of Positive and negative selection in thymus
● Control of CD4 T cell differentiation via regulation of ThPok, Gata-3 and Runx-3
4. Neural development and early progenitor cells differentiation
● Role of chromatin remodeling complex for hippocampus development and Hematopoiesis
● Control of cell differentiation and proliferation of thymocytes by pre-TCR and TCR signaling
● Control of positive and negative selection by chromatin remodeling complex
2. Biogenesis of regulatory T-cells
● Control of regulatory T-cell development by chromatin remodeling complex
3. Role of transcription factor,Twist2 in T cell development
● Control of Positive and negative selection in thymus
● Control of CD4 T cell differentiation via regulation of ThPok, Gata-3 and Runx-3
4. Neural development and early progenitor cells differentiation
● Role of chromatin remodeling complex for hippocampus development and Hematopoiesis
Education/Career
Education
- - 2003.4-2024.2 Professor
- - 1997.2-2003.3 Associate Professor
- - 1993.3-1997.2 Assistant Professor
- - 1983.10-1990.1 Ph.D. : Stanford University, U.S.A.
- - 1981.3-1983.2 Master
- - 1977.3-1981.2 Bachelor
Career
- - 2007.1-Present Secretary General, The World Society of Cell Biology Organizing Committee
- - 2005.1-2005.12 General Affairs Operator, Korean Society for Molecular and Cellular Biology
- - 2005-Present RCFC Director, Research Center of Cell Function Control appointed by Ministry of Science and Technology / Science Foundation
- - 2004.1-Present Director, Korea Aid Association of National Vaccine Research Center
- - 2003.3-2005.12 Bio-MAX Institute Project Operation Department Head, Seoul National University Bio-MAX Institute
- - 2003. 4 - Present Professor, School of Biological Sciences, Seoul National University
- - 2002.5-2007.4 International Research Advisor, International Vaccine Research Center
- - 2001.1-2002.12 Editor, Molecules and Cells (Journal of Korean Society for Molecular and Cellular Biology)
- - 1999.1-2003.1 Director, Seoul National University SPF
- - 1997.4-2003.3 Associate Professor, Seoul National University Institute of Molecular Biology and Genetics
- - 1996.12-Present Board Chairman, Korean Zoology Association
- - 1996.12-2000.11 Editor, Journal of Association of Korean Biological Sciences
- - 1995.12-Present Board Chairman, Korean Immunology Association
- - 1994.12-1996.11 Scientific Organizer, Korean Zoology Association
- - 1993.3-1997.3 Assistant Professor, Seoul National University Institute of Molecular Biology and Genetics
Publications
- S. Lee, J. Kim, H. Min, R.H. Seong. 2020. RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23, 101106
- S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong. 2020. Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff https://doi.org/10.1038/s41418-020-0560-x
- W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong. 2019. Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 25;116(26):12952-12957.
- Lee S, Park K, Kim J, Min H, Seong RH. 2018. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep. 19(12):e45995
- Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6" for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
- Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
- Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
- Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
- Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.